Research advances of Rab1A in the development of cancer

VernacularTitle:Rab1A与肿瘤发生发展的研究进展
Author: Zheng-Wu CHENG ¹ ; Zi-Kang WANG
Author Information

1. 苏州大学附属第一医院普外科
Keywords: Rab1A; mammalian target of rapamycin complex 1; signaling pathways; tumor
From: Journal of Medical Postgraduates 2018;31(1):73-76
CountryChina
Language:Chinese
Abstract: Rab1A is a member of the RAB family as a small GTPase and a mammalian target of rapamycin complex 1 (mTORC1) Activator,which has been well established to mediate vesicular trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus. With increasingly deep research of Rab1A,many researchers discover that Rab1A protein is also involved in mediating signal transduction,cell migration and regulation of autophagy. Meanwhile,aberrant expression of Rab1A has been linked to a range of human diseases as well,including Parkinson's disease,cardiomyopathy,and aspirin-exacerbated respiratory disease. Recently Rab1A research has gradually shifted to its role in occurrence and development of tumor,and researchers also discover that Rab1A was abnor-mally expressed in many malignant tumors such as tonguesquamous carcinoma,breast cancer,human lung cancer,hepatocellular carci-noma,colorectal cancer,gastric cancer and cervical cancer. Besides that,over expression of Rab1A plays a significant role in the pro-gression of different tumors. This article summarizes the research progress of Rab1A intumor development and signaling pathways.