Correlation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with the prognosis of endom-etrial carcinoma
10.16571/j.cnki.1008-8199.2018.01.013
- VernacularTitle:术前外周血中性粒细胞及血小板与淋巴细胞比值对子宫内膜癌患者预后的影响
- Author:
Wen LI
1
;
Lu WANG
;
Jun-Cheng ZHANG
;
San-Meng WANG
;
Can WANG
;
Tian-Tian YU
;
Wu-Liang WANG
Author Information
1. 郑州大学第二附属医院妇产科
- Keywords:
endometrial cancer;
neutrophil-to-lymphocyte ratio;
platelet-to-lymphocyte ratio;
prognosis
- From:
Journal of Medical Postgraduates
2018;31(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective Endometrial cancer (EMC) is a most common malignancy in the female reproductive system. The purpose of this study was to investigate the relationship of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the prognosis of EMC. Methods We retrospectively analyzed the clinical and follow-up data about 153 EMC patients surgically treated in the Second Affiliated Hospital of Zhengzhou University. Based on the cutoff values of NLR and PLR, we divided the patients into a high and a low value group,and analyzed the relationships of NLR and PLR with clinical pathological features and prognosis of the patients. Results There were statistically significant differences between the high value group(NLR>3.40) and the low value group (NLR≤3.40) in the FIGO stage,pathological grade,invasion depth,and lymph node metastasis(P<0.05). No sig-nificant correlation was found between the PLR and the prognosis EMC (P>0.05). COX regression analysis showed that FIGO stageⅢ-Ⅳ (P<0.001),pathological grade G3(P=0.022) and NLR>3.4(P=0.004) were independent risk factors for the overall surviv-al and disease-free survival of the EMC patients. Conclusion High preoperative NLR was closely related with the FIGO stage, pathological grade,invasion depth,and lymph node metastasis in pa-tients with endometrial cancer.
