The value of DWI in monitoring therapeutic effects of Cyberknife on pain for locally advanced pancreatic cancer
10.3760/cma.j.issn.1674-1935.2018.03.005
- VernacularTitle:射波刀治疗局部进展期胰腺癌疼痛的近期疗效及DWI的评估价值
- Author:
Yu ZHANG
1
;
Jianfeng FEI
;
Huojun ZHANG
;
Zhitao DAI
;
Wei CHEN
;
Chao MA
;
Jianping LU
Author Information
1. 第二军医大学长海医院放射科
- Keywords:
Pancreatic neoplasms;
Radiotherapy;
Cyberknife;
Duffusion weighted imaging;
Pain
- From:
Chinese Journal of Pancreatology
2018;18(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term therapeutic efficacy of Cyberknife in alleviating the pain of locally advanced pancreatic cancer (LAPC) and explore the application of DWI in the pain evaluation.Methods Visual analogue scale (VAS) and Quality of life score KPS were conducted in 36 LAPC patients before and 1 month,3 month after radiotherapy,who underwent conventional MRI examination and DWI scan.The changes of VAS and KPS scores were observed before and after the treatment,as well as the apparent diffusion coefficients (ADC) changes of region of interest (ROI) in the DWI images,and the correlation of ADC with KPS and VAS was analyzed.Results VAS before and at 1 month and 3 month after the treatment was (4.89 ± 2.89),(1.08 ± 2.06) and (0.51 ± 1.48).KPS before and at 1 month and 3 month after the treatment was (72.47 ± 14.74),(93.33 ± 10.69) and (92.86 ± 10.73).ADC of DWI before and at 1 month and 3 month after the treatment was 1.47 ± 0.28,1.79 ± 0.33 and 1.94 ± 0.41,and the differences were statistically significant (all P values ＜0.001).VAS was obviously decreased at 1 month and 3 month after the treatment,while KPS and ADC were greatly increased,and the differences were statistically significant (P value ＜ 0.05).There was no statistical difference between those at 1 month and those at 3 month.There was no obvious correlation between ADC and VAS and KPS at 1 month and 3 month after the treatment.Conclusions After Cyberknife treatment,the pain was obviously relieved and the life quality was greatly improved within short period,but ADC of DWI can not sensitively monitor the changes of the pain.
