Efficacy and safety of stereotactic body radiation therapy for very elderly patients with pancreatic cancer
10.3760/cma.j.issn.1674-1935.2018.02.007
- VernacularTitle:立体定向放射治疗高龄胰腺癌患者的疗效及安全性分析
- Author:
Yin TANG
1
,
2
;
Xiaofei ZHU
;
Xianzhi ZHAO
;
Yangyang GENG
;
Lingong JIANG
;
Haiyan YU
;
Hongyu MENG
;
Yu ZHANG
;
Huojun ZHANG
Author Information
1. 200433 上海,第二军医大学长海医院放疗科
2. 解放军第371医院
- Keywords:
Pancreatic neoplasms;
Aged;
Cyberknife;
Radiotherapy;
Stereotaxic techniques
- From:
Chinese Journal of Pancreatology
2018;18(2):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of stereotactic body radiation therapy (SBRT) for very elderly patients with pancreatic cancer.Methods The clinical data of a total of 149 patients aged from 75 to 90 years with locally advanced or metastatic pancreatic cancer treated by SBRT in Changhai Hospital from January 2012 to December 2016 were retrospectively reviewed.Prescription doses ranged from 3.6-9Gy/fractions,and the total doses were 19.5-49Gy in 3-8 fractions.The level of serum cancer antigen 19-9(CA19-9) before and 3 months after treatment was compared and the radiotherapy biological effective dose (BED10) was calculated.The adverse events of the radiotherapy were observed.Overall survival (OS) and progression-free survival (PFS) were recorded through follow-up,and the factors influencing the patients' survival were investigated by univariate and multivariate analysis.Results All the patients' median OS and PFS were 12.9and 8.3 months,respectively.One-year OS and PFS rate were 55.9％ and 19.5％,respectively.Tumor stage and the decrease of CA19-9 levels ＞50％ at 3 months after treatment and BED10 were independent factors of OS and PFS.No grade 3 or higher toxicities were recorded in all the patients.Conclusions SBRT is safe and effective for very elderly patients with locally advanced or medically inoperable pancreatic cancer.Tumor stage,the decrease of CA19-9 levels after treatment and BED10 were associated with prognosis.
