Organ endangering dose and side effects in two courses of stereotactic body radiation therapy for pancreatic cancer
10.3760/cma.j.issn.1674-1935.2018.01.010
- VernacularTitle:胰腺癌二次立体定向放射治疗的危及器官剂量和不良反应
- Author:
Lingong JIANG
1
;
Xiaofei ZHU
;
Yangsen CAO
;
Xiaoping JU
;
Yin TANG
;
Haiyan YU
;
Huojun ZHANG
Author Information
1. 第二军医大学长海医院放疗科
- Keywords:
Pancreatic neoplasms;
Radiotherapy;
Radiotherapy planning;
computer-assisted;
Stereotaxic techniques
- From:
Chinese Journal of Pancreatology
2018;18(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the cumulative doses and side effects after two courses of stereotactic body radiation therapy (SBRT) for pancreatic cancer. Methods Twenty-four pancreatic cancer patients who received two courses of SBRT were enrolled. Organ endangering dose accumulations were calculated by rigid and non-rigid registration. All doses were recalculated to an equivalent dose of 2 Gy per fraction. Results The median of accumulated maximal dosage (Dmax) and dosage per 1cc(D1cc) of the stomach,duodenum and the bowel were 43.87 and 35.28 Gy 3,35.53 and 26.59 Gy3,45.08 and 36.18 Gy3; and the median volume under the dosage of 10Gy (V10) was 107.40,23.98 and 169.26cc, respectively. The median accumulated Dmaxand the dosage of 35% volume(D0.35) of the spinal cord was 8.42 and 7.83Gy3. The median cumulative Dmeanand D2/3of the left and right kidney were 5.18 and 3.65 Gy3, 3.50 and 2.57 Gy3, respectively. The median cumulative Dmeanand D50%of the liver was 5.18 and 3.64Gy3,respectively. The median summed dose to the overlapping radiation field of the two courses was 93.38 Gy3. No grade 3-4 toxicity occurred. Conclusions The cumulative doses to organs at risk as dose constraints were safe and acceptable,which could be used as a reference to evaluate whether a second SBRT could be done after initial SBRT for pancreatic cancer.
