Advances in tumor-endothelial cells co-culture and interaction on microfluidics
- Author:
Weiwei LI
1
;
Mashooq KHAN
;
Sifeng MAO
;
Shuo FENG
;
Jin-Ming LIN
Author Information
1. Department of Chemistry
- Keywords:
Microfluidic;
Cell analysis;
Cell co-culture;
Cell interaction;
Review
- From:
Journal of Pharmaceutical Analysis
2018;8(4):210-218
- CountryChina
- Language:Chinese
-
Abstract:
The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade to the sur-rounding and far tissues of the body is the leading cause of mortality in cancer patients. With a lot of advancement in the field, yet the biological cause of metastasis are poorly understood. The microfluidic system provides advanced technology to reconstruct a variety of in vivo-like environment for studying the interactions between tumor cells (TCs) and endothelial cells (ECs). This review gives a brief account of both two-dimensional models and three-dimensional microfluidic systems for the analysis of TCs-ECs co-culture as well as their applications to anti-cancer drug screening. Furthermore, the advanced methods for analyzing cell-to-cell interactions at single-cell level were also discussed.
