Role of glial cell in cerebral hemorrhage injury and potential targets for intervention
10.3760/cma.j.issn.1673-4904.2018.11.021
- VernacularTitle:神经胶质细胞在出血性脑损伤中的作用及可能的干预靶点
- Author:
Minshu LI
1
;
Honglei REN
;
Xiaodong ZHU
;
Baocheng CHANG
Author Information
1. 300052,天津医科大学总医院神经内科 天津市神经病学研究所
- Keywords:
Cerebral hemorrhage;
Neuroglia;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(11):1042-1046
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral hemorrhage is one of the refractory diseases which seriously endangers the safety of human life. Immune and inflammatory reaction participate in the whole process of cerebral hemorrhage, which can destroy the blood-brain barrier, accelerate brain edema, at the same time start and amplify the oxidative stress reaction, and aggravate the nerve function damage. After cerebral hemorrhage, many kinds of signal molecules are produced, which can activate the microglia and astrocytes around the hematoma, produce inflammatory factors and oxidizing mediators, and regulate the inflammatory response of the brain. Exploring the relationship between glial cell and immune, inflammatory responses is helpful to understand the mechanism of intracerebral hemorrhage intervention, find out a new target for the intervention of glial cells and develop new drugs and schemes for the treatment of intracerebral hemorrhage.
