Research progress of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis
10.3760/cma.j.issn.1673-4904.2018.10.023
- VernacularTitle:血管内皮生长因子在类风湿性关节炎发病机制中的研究进展
- Author:
Shancui ZHENG
1
;
Lei LIU
;
Xueming SUN
;
Junjun CAO
;
Jia TANG
Author Information
1. 215300,江苏省昆山市第一人民医院风湿免疫科
- Keywords:
Rheumatoid arthritis;
Vascular endothelial growth factor;
Synovial pannus formation;
Joint erosion and destruction;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(10):957-960
- CountryChina
- Language:Chinese
-
Abstract:
Essential of rheumatoid arthritis (RA) is destruction of invasive pannus formation in cartilage, bone and surrounding tissues Chronic inflammation of synovial membrane. Vascular endothelial growth Factor (VEGF) increases vascular permeability and induces angiogenesis. It plays a very important role in the process of joint erosion and destruction of RA. It not only promotes the formation of RA synovial pannus formation, but also acts as a direct proinflammatory factor in the pathogenesis of RA.
