Risk factors analysis of central neck lymph node metastases in clinically node-negative papillary thyroid carcinoma and the rationality of prophylactic central neck dissection
10.3760/cma.j.issn.1673-4904.2018.10.004
- VernacularTitle:临床淋巴结阴性的甲状腺乳头状癌中央区淋巴结转移的高危因素及预防性清扫的合理性探究
- Author:
Qiufeng JIN
1
;
Peng LI
;
Jinxing QI
;
Shasha ZHANG
Author Information
1. 450003,郑州大学附属肿瘤医院头颈甲状腺外科
- Keywords:
Thyroid;
Papillary thyroid carcinoma;
Central lymph node;
Lymph node metastasis;
Lymph node dissection
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(10):878-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of central neck lymph node metastases in clinically node-negative (cN0) papillary thyroid carcinoma (PTC) and the rationality of prophylactic central neck dissection. Methods The clinical data of 1359 patients who had underwent PTC treatment at the Department of Head and Neck Surgery , Henan Provincial Cancer Hospital during the five years (from 2011-01 to 2015-12) were analyzed retrospectively. Results There were 376 patients (27.67％, 376/1359) with central neck lymph node metastases. Single factor analysis and multivariate Logistic regression analysis showed that the central neck lymph node metastases were related to tumor max diameter≥10 mm, extrathyroidal extension (P<0.01), age<55 years old (P<0.01), multifocality (P<0.01), and PTC located at the isthmus (P<0.01). Conclusions Risk stratification should be performed on cN0 PTC. Prophylactic central neck dissection should be performed in cN0 patients with the tumor max diameter ≥ 10 mm, capsule invasion, age <55 years, multiple tumors, isthmus PTC and Hashimoto thyroiditis patients.
