The role of high mobility group protein B1 in pain caused by inflammatory reaction in endometriosis
10.3760/cma.j.issn.1673-4904.2018.09.025
- VernacularTitle:高迁移率族蛋白B1在子宫内膜异位症炎性反应致疼痛中的作用
- Author:
Xin YIN
1
;
Guangyu BIAN
;
Deying WANG
;
Haizhu SUN
;
Xiaohong QIU
Author Information
1. 150086,哈尔滨医科大学附属第二医院妇产科四病房
- Keywords:
High mobility group proteins;
Endometriosis;
Inflammation;
Pain;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(9):860-864
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group protein B1 (HMGB1) is a DNA binding protein that can induce cytokines to be secreted and activate inflammatory cells to participate in inflammatory reactions. Recent studies on its role in the inflammatory response to endometriosis have gradually increased. Endometriosis is a benign inflammatory disease with increasing incidence year by year, mostly in women of childbearing age. This disease mainly causes the clinical manifestations of dysmenorrhea and chronic pelvic pain. Endometriosis usually plays a synergistic role in inflammatory immune, lesion tissue invasion, adhesion and other factors, resulting the changes in the pelvic microenvironment. The mechanism of endometriosis is not completely clear, but the role of inflammatory reaction and stimulation can not be ignored. HMGB1 can increase the release of inflammatory factors and cause the body to produce pain, and the expression of HMGB1 in the endometriosis patients is significantly increased. The inflammatory response and pain can be alleviated by reducing the concentration of HMGB1 in the body of endometriosis patients. Pain and other symptoms suggest that HMGB1 may become an important target for the treatment of endometriosis.
