Regulatory effects and mechanism about iRGD-functionalized nanomicelles on colorectal cancer multidrug resistance
10.3760/cma.j.issn.1673-4904.2018.09.023
- VernacularTitle:iRGD肽修纳米胶束对结直肠肿瘤耐药效应的调节作用及机制
- Author:
Yuxi YANG
1
;
Zhongwei JI
;
Yuhong ZHANG
;
Liuping YOU
;
Yuenan HUANG
Author Information
1. 150086,哈尔滨医科大学附属第二医院普外科
- Keywords:
Drug resistance;
neoplasm;
Colorectal neoplasms;
iRGD peptid;
Nanomicelles
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(9):852-855
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, conventional targeting of chemotherapeutic drugs on colorectal tumor tissue is poor in the clinical application. Due to the multidrug resistance of colorectal tumors, penetration and cytotoxicity of conventional drugs greatly reduced on tumor tissue. With the advent of tumor-penetrating peptides, a new and highly effective antitumor drug delivery system has become a research topic of international scholars. This article will briefly describe the research progress of iRGD peptides with the modified nanomicelles drug delivery system on targeted drug delivery and resistance to drug-resistant colorectal tumors in recent years. These studies show that iRGD peptide-modified nanomicelles will be a highly potential anti-drug delivery system.
