Expression of Foxp3+regulatory T cells and programmed death receptor 1 in epithelial ovarian cancer and its clinicopathological significance
10.3760/cma.j.issn.1673-4904.2018.06.013
- VernacularTitle:Foxp3+调节性T细胞及程序性死亡受体1在上皮性卵巢癌组织中的表达及临床病理意义
- Author:
Xiaoli LIU
1
;
Zhiming YANG
;
Lili WANG
;
Jing WANG
Author Information
1. 冀中能源峰峰集团总医院北院区妇产科
- Keywords:
T-lymphocytes;
Ovarian neoplasms;
Programmed death receptor 1;
Clinical Pathology
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(6):532-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the expression of Foxp3+ regulatory T cells (Foxp3+ Tregs) and programmed death receptor 1 (PD1) in epithelial ovarian cancer tissues and its clinicopathological significance. Methods One hundred and twenty-nine patients with epithelial ovarian cancer were selected from June 2011 and June 2014. Immunohistochemical method was used to detect the expression of Foxp3+ Tregs and PD1 in the epithelial ovarian cancer tissue and the normal tissue adjacent to the carcinoma. The clinicopathological relationship between the expression of Foxp3+ Tregs and PD1 of epithelial ovarian cancer were analyzed. Results The positive expression rate of Foxp3+Tregs and PD1 in epithelial ovarian cancer was significantly higher than that of normal tissue adjacent to the carcinoma [71.32%(92/129) vs. 1.55%(2/129), 65.89%(85/129) vs. 3.10%(4/129)], the difference was statistically significant (P<0.05). The expression of Foxp3+Tregs and PD1 in epithelial ovarian cancer was related to lymph node metastasis, TNM staging, and degree of differentiation (P<0.05), it was not related to the age, the size of the tumor, and the pathological type of the patients (P > 0.05). During the follow-up period of 3 years, the survival rate of patients with expression of Foxp3+ Tregs was significantly lower than that of the negative expression: 21.74%(20/92)vs.78.38%(29/37), the survival rate of patients with PD1 positive expression was significantly lower than that of the negative expression:28.24% (24/85) vs.56.82%(25/44) , P < 0.05. There was a positive correlation between the expression of Foxp3+ Tregs and PD1 in epithelial ovarian cancer (P < 0.05). Conclusions The abnormal expression of Foxp3+Tregs and PD1 in epithelial ovarian cancer is related to the development of tumour, it can be used as an important biomarker to evaluate the pathological progress and prognosis of patients. It is worth for further clinical promotion.
