The study on the relationship between the levels of sonic hedgehog and vascular endothelial growth factor in serum and cerebral collateral circulation in patients with symptomatic cerebral artery stenosis
10.3760/cma.j.issn.1673-4904.2018.06.006
- VernacularTitle:症状性大脑中动脉狭窄患者血清音猬因子、血管内皮生长因子水平与脑侧支循环形成的相关性研究
- Author:
Liuying ZHANG
1
;
Xin ZHAO
;
Weifei WANG
;
Hao SUN
;
Miaomiao ZHAO
;
Xiaoting WANG
;
Guifeng ZHANG
;
Li LI
;
Zhangyong XIA
;
Jiyue WANG
Author Information
1. 271016,泰山医学院研究生部
- Keywords:
Stroke;
Sonic hedgehog;
Vascular endothelial growth factor;
Collateral circulation;
Biomarkers
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(6):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the levels of sonic hedgehog (SHH) and vascular endothelial growth factor (VEGF) in serum and its relationship with collateral circulation in patients with symptomatic middle cerebral artery stenosis. Methods From January 2015 to January 2018, a total of 268 patients with acute ischemic stroke confirmed as unilateral middle cerebral artery M1 segment (MCA-M1) severe stenosis or occlusion by digital subtract angiography (DSA) were enrolled. The baseline clinical data were collected. According to the establishment of collateral circulation shown by DSA, they were divided into good collateral circulation group (152 patients) and poor collateral circulation group (116 patients). The levels of SHH and VEGF in serum were detected by enzyme linked immunosorbent assay (ELISA), the expression characteristics of SHH and VEGF in serum and the relative factors influencing the establishment of collateral circulation were analyzed. Results The levels of serum SHH and VEGF in good collateral circulation group were significantly higher than those in poor collateral circulation group (P < 0.01). Pearson correlation analysis showed that there was a positive correlation between SHH and VEGF (r=0.758, P < 0.01). Multivariate Logistic regression analysis showed that the levels of serum SHH ( OR=0.310, 95% CI 0.117-0.819, P=0.018) and VEGF ( OR=0.361, 95% CI 0.147-0.887, P=0.026) were independent protective factors for the establishment of collateral circulation. Diabetes ( OR=3.094, 95% CI 1.321-7.245, P=0.009) was independent risk factor for the establishment of collateral circulation. Conclusions The levels of serum SHH and VEGF are closely related to the formation of collateral circulation and they are independent protective factors. SHH may be involved in the establishment of cerebral collateral circulation by regulating the expression of VEGF and diabetes is not conducive to the formation of collateral circulation.
