Curative effect analysis of thrombolytic therapy in acute cerebral infarct patients with atrial fibrillation
10.3760/cma.j.issn.1673-4904.2018.04.004
- VernacularTitle:伴有心房颤动的急性脑梗死患者静脉溶栓疗效分析
- Author:
Maoxiang WANG
1
;
Xiaodong WANG
;
Tieping FAN
;
Xusheng ZHAO
;
Daoyong PENG
Author Information
1. 116033,大连市中心医院神经内科
- Keywords:
Atrial fibrillation;
Cerebral infarction;
Intravenous thrombolysis;
Hemorrhagic transformation;
Comparative study
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(4):301-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk of hemorrhagic transformation and the curative effect in patients with atrial fibrillation(AF)treated by intravenous thrombolysis with alteplase after acute cerebral infarct. Methods The clinical data of 246 patients with acute cerebral infarct treated with intravenous alteplase within 4.5 h from the onset were analyzed.According to the presence or absence of AF, the patients were divided into AF group (74 cases) and non AF group (172 cases). The outcomes were the incidence of hemorrhagic transformation within 36 h and the curative effect after 2 weeks. Results The incidence of hemorrhagic transformation in AF group was 31.1%(23/74), in non AF group was 7.6%(13/172),and there was significant difference(χ2=22.917,P=0.000).The effective rate in AF group was 54.1%(40/74), in non AF group was 76.7%(132/172), and there was significant difference (χ2=12.665,P=0.000).Conclusions Patients with acute cerebral infarction combined with AF have a high risk of hemorrhagic transformation and poor prognosis after intravenous thrombolysis.
