Efficacy of tigecycline- based treatment approach on severe infection in patients with hematological diseases
10.3760/cma.j.issn.1673-4904.2018.04.003
- VernacularTitle:替加环素为基础的联合方案治疗恶性血液病患者重症感染的临床疗效
- Author:
Lixiao SONG
1
;
Shandong TAO
;
Wenting SHI
;
Yuan DENG
;
Lanlan LING
;
Banghe DING
;
Chunling WANG
;
Liang YU
Author Information
1. 223300,南京医科大学附属淮安第一医院血液科
- Keywords:
Tigecycline;
Treatment outcome;
Combined treatment
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(4):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of tigecycline-based treatment approach on severe infection of patients with hematological diseases. Methods The clinical data of 64 patients who were treated with tigecycline-based treatment approach for severe infection were retrospectively reviewed. The curative effect was evaluated, meanwhile the drug side effects were observed. Results A total of 51 strains of bacteria were isolated from 64 patients, including 12 extended-spectrum β-lactamase(ESBL)and 15 multi-drug resistant strains and the total effective rate was 59.4%(38/64). Five patients diagnosed as carbapenem resistant infection and were treated with the addition dose of tigecycline and 3 patients relieved. Main adverse events were nausea, vomiting, diarrhea and hepatic dysfunction, but all events were slight. Conclusions Tigecycline-based treatment approach has a good clinical efficacy in treating severe infection of patients with hematological diseases, and the side effect is few.Tigecycline-based treatment approach could be used as a new choice for patients non-responding favorably to conventional anti-infective treatment or multiple resistant bacteria.
