Study on changes of T-lymphocyte subsets (CD3, CD4, CD8) in kidney transplant recipients
- Author:
Manh Van Bui
;
Don Van Le
- Publication Type:Journal Article
- Keywords:
Kidney transplant;
- MeSH:
Kidney transplant;
- From:Journal of Medical and Pharmaceutical Information
2003;0(5):24-26
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Chronic renal failure patients with end-stage must be treated with renal replacement methods such as artificial kidneys, renal peritoneum purification or kidney transplant, in which kidney transplant is considered as the optimal method.\r\n', u'Objectives: To study changes of lymphocyte subsets (CD3, CD4, CD8) in kidney transplant recipients.\r\n', u'Subjects and methods: A prospective descriptive study was performed on 80 people including 45 healthy people and 35 patients with transplanted kidney over two years.\r\n', u'Results and conclusion: The average number of lymphocyte subsets in adult healthy people were determined in this study, as follows: TCD4: 540 \xb1 177 tb/\u03bcl, TCD8: 728 \xb1 208 tb/\u03bcl; TCD3: 1389 \xb1 372 tb/\u03bcl; TCD4/TCD8: 0.39 \xb1 0.08; TCD4/TCD3: 0.76 \xb1 0.23 and TCD8/TCD3: 0.76 \xb1 0.23. There was no significant difference in mean number of TCD4 between pre-transplant and 1 year and 2 years post transplantation (p >0.05) but TCD4/TCD8 ratio was significantly decreased at both 1 year and 2 years post-transplantation (p<0.001). TCD4/TCD8 ratio was not significantly different between 1 year and 2 years after transplantation (p >0.05)\r\n', u'\r\n', u'
