Experimental study on skin irritation and anaphylaxis of liquid bandage

VernacularTitle:液体绷带皮肤刺激性和过敏性实验研究
Author: Li-Hai ZHANG ¹ ; Yi LU ; Ya-Wei WANG ; Jing LIU ; Mei LIU ; Bo YANG ; Yan QIU ; Sheng LYU
Author Information

1. 南京江宁区秣陵社区卫生服务中心
Keywords: liquid bandage; skin irritation; anaphylaxis; animal experiment; medication safety
From: Chinese Medical Equipment Journal 2018;39(3):19-22,26
CountryChina
Language:Chinese
Abstract: Objective To observe the skin irritation and anaphylaxis of the liquid bandage to facilitate its safety evaluation. Methods In case of skin irritation test,some New Zealand rabbits were divided into an unaffected skin group and an affected skin group, and had their skin observed for erythema, edema and etc after undergoing 1-d and 7-d administration respectively;in case of anaphylaxis,the guinea pigs went through drug sensitization respectively at the 1st,7th and 14th days and experienced re-sensitization 14 days after,and the symptoms of anaphylaxis were observed such as erythema and edema. Results The liquid bandage had no irritation to the unaffected and affected skin of New Zealand rabbit by single or multiple administration with the irritation mean value being lower than 0.5.There were no anaphylaxis symptoms such as erthema and edema found in the guinea pig by the liquid bandage.Conclusion The liquid bandage proves its skin safety by non-irritation to the unaffected and affected skin of New Zealand rabbit and non-anaphylaxis to the guinea pig.