Research progress of ocular surface reconstruction with ex vivo cultured tissue engineered cell sheet

VernacularTitle:体外培养组织工程细胞膜片重建眼表研究进展
Author: Fuyan WANG ^{1
,

2}
Author Information

1. 250012济南,山东大学齐鲁医学院
2. 266071青岛,山东省眼科研究所山东省眼科学重点实验室-省部共建国家重点实验室培育基地
Keywords: Limbus cornea; Epithelial cells,corneal; Oral mucosal epithelial cells; Ocular surface reconstruction; Limbal stem cell deficiency
From: Chinese Journal of Experimental Ophthalmology 2018;36(11):887-891
CountryChina
Language:Chinese
Abstract: Limbal stem cells (LSCs),the source of corneal epithelial cells,play an important role in the ocular surface. In recent years, with the development of somatic stem cell application and tissue engineering, biomaterials and cell culture technology,progress has been made on the basic researches and clinical applications of ocular surface reconstruction with ex vivo cultured limbal epithelial and oral mucosal epithelial cell sheet transplantation. However, there are several issues, including the successful clinical outcomes for ocular surface reconstruction,and the in vivo tracking of donor stem cells,remained indefinitive. This article introduced and compared recent advancements of tissue engineering techniques ex vivo cultured autologous or allogeneic limbal,oral mucosal epithelial cells in ocular surface reconstruction,so as to provide a useful direction for the future research of ocular surface reconstruction.