Clinical features of cancer-associated retinopathy
10.3760/cma.j.issn.2095-0160.2018.10.011
- VernacularTitle:癌症相关性视网膜病变的临床特征
- Author:
Hui LI
1
;
Lizhu YANG
;
Xuan ZOU
;
Zixi SUN
;
Ruifang SUI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院眼科
- Keywords:
Cancer-associated retinopathy;
Immune retinopathy;
Clinical features
- From:
Chinese Journal of Experimental Ophthalmology
2018;36(10):786-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of cancer-associated retinopathy (CAR).Methods The clinical data of 10 patients who diagnosed as CAR during 5 years were retrospectively analyzed.All patients underwent detailed ocular examinations,including electroretinogram (ERG),optical coherence tomography (OCT),visual field (VF) and autofluorescence(AF).Results The primary malignancy was lung carcinoma in 3 patients,thymoma in 3 patients,thyroid carcinoma in 1 patients,maxillary sinus tumor in 1 patients,nasopharyngeal carcinoma in 1 patients and rectal cancer in 1 patients.All patients complained progressive visual reducing.Three patients manifested night blindness.The best corrected visual acuity (BCVA)＜0.1 was in three eyes,≤0.1-＜0.5 in seven eyes,and ≥0.5 in ten eyes.Patients showed normal fundi or mild abnormality.OCT images showed disorganization and/or loss of the ellipsoid zone in the macular area in 4 patients,and other six patients had only central foveal ellipsoid zone preserved.Eight patients had moderately or severely reduced ffERG,and 2 patients demonstrated electro-negative ERG.Five patients revealed peripheral visual defect.AF images were from normal to low or high AF patches in the posterior pole and mid-peripheral retina.Conclusions The clinical manifestations of CAR are varied as common characteristics of progressive visual decrease with or without night blindness,visual field defect and abnormal ffERG recording.
