Clinical features and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation
10.3760/cma.j.issn.2095-0160.2018.06.009
- VernacularTitle:泪腺腺样囊性癌高级别转化临床预后分析
- Author:
Bo ZHOU
1
;
Tingting LIN
;
Xun LIU
;
Limin ZHU
;
Yanjin HE
Author Information
1. 300384,天津医科大学眼科医院
- Keywords:
Orbital neoplasms;
Carcinoma,adenoid cystic;
High-grade transformation;
Clinical features;
Prognosis
- From:
Chinese Journal of Experimental Ophthalmology
2018;36(6):442-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical characteristics and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation (LACC-HGT).Methods A retrospective study was adopted.Seventeen patients with lacrimal gland adenoid cystic carcinoma (LACC) were collected from August 2008 to March 2017 in Tianjin Medical University Eye Hospital.Hematoxylin-eosin staining and immunohistochemical staining were performed on tumor sections of 17 LACC patients.According to the pathology results,the patients were divided into LACC-HGT group (6 patients) and non-LACC-HGT (NLACC-HGT)group (11 patients),and the clinical characteristics and prognosis of the two groups were analyzed by using Fisher's exact test and Log-Rank test.Results The medical histories,clinical features,imaging features,TNM staging and treatment protocols were not significantly different between the two groups (all at P＞ 0.05).The 2-year local recurrence rate,5-year distant metastasis rate and 5-year death rate of patients with LACC-HGT were significantly higher than patients with NLACC-HGT (all at P＜0.05).Survival analysis results showed that the survival time of LACC-HGT group was obviously shorter than that of NLACC-HGT group.Conclusions LACC-HGT accelerate the invasion process of local recurrence and distant metastasis,and enhance the death rate.The detection of HGT components should be considered in the process of LACC diagnosis.
