Two Cases of Sex-linked Ichthyosis Improved by an Oral Aromatic Retinoid (Ro 10 - 9359).
- Author:
Joo Eun JANG
;
Hong Il KOOK
- Publication Type:Case Report
- MeSH:
Arthralgia;
Body Weight;
Child;
Diagnosis;
Humans;
Ichthyosis*;
Knee Joint;
Lower Extremity;
Male;
Mouth;
Nose;
Paronychia;
Skin;
Upper Extremity;
Weights and Measures;
Young Adult
- From:Korean Journal of Dermatology
1982;20(3):431-436
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present the therapeutic effects of an aromatic retinoid (Ro 10-9359) in two cases of sex-linked ichthyosis. Case 1, Uncle of Case 2, was a 24-year-old male who had had dark brown scales on the trunk and upper extremities for 15 years. Case 2 was a 10-year-old boy who had had dirty brown scales on the trunk and lower extremities since 3 years of age. The diagnosis of sex-linked ichthyosis was made by characteristic scales and histopathologic findings. Initially, both patients received an oral aromatic retinoid (Ro 10-9359) with a daily dose of 1.5mg/kg body weight for the first two weeks. Thereafter the drug was tapered gradually to the dose of 0.5mg/kg body weight according to the therapeutic response. There was near complete clearing of the skin lesions in both patients after 10 weeks treatment. Side effects were of mild intensity and included dryness of mouth and nose, chelitis, paronychia and arthralgia of knee joint.
