Intra-arterial chemotherapy for the treatment of retinoblastoma
10.13389/j.cnki.rao.2018.0090
- VernacularTitle:经眼动脉介入化学疗法治疗视网膜母细胞瘤的研究进展
- Author:
Xue-Hao CUI
1
;
Xun-Da JI
;
Pei-Quan ZHAO
Author Information
1. 上海交通大学医学院附属新华医院眼科
- Keywords:
retinoblastoma;
therapy;
chemotherapy;
interventional
- From:
Recent Advances in Ophthalmology
2018;38(4):385-388
- CountryChina
- Language:Chinese
-
Abstract:
Intra-arterial chemotherapy (IAC) refers to the injection of chemotherapeutics into patients' eyes through arteria ophthalmica in order to local chemotherapy for retinoblastoma (RB).The common drugs in the treatment of RB include melphalan,topotecan and carboplatin.IAC can form the high-concentration drug effects on local areas.It can effectively kill tumors and significantly reduce the occurrence rate of complications after intravenous chemotherapy.Application of IAC can cure patients with RB in B,C,D and E stage in international criteria,which can effectively improve eye protection rate.Complications of IAC include eyelids edema,chemosis,blepharoptosis,ocular motility disorders,vitreous hemorrhage,ischemia of choroid or retina,transient myelosuppression,etc.It should be further conduction of long-term and large-sample cases studies on how to improve curative effects and reduce serious eye complications.
