Expression of monocyte chemoattractant protein-1 in aqueous humor of patients with primary acute angleclosure glaucoma and its association with the patients' prognosis after trabeculectomy
10.13389/j.cnki.rao.2018.0056
- VernacularTitle:单核细胞趋化蛋白-1在原发性急性闭角型青光眼患者房水中的表达及其与小梁切除术预后的关系
- Author:
Hong-Xia WANG
1
;
Yong-Hua LI
;
Xiu-Hua GAO
Author Information
1. 济宁医学院附属医院眼科
- Keywords:
primary acute angle-closure glaucoma;
monocyte chemoattractant protein-1;
risk factors
- From:
Recent Advances in Ophthalmology
2018;38(3):242-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the levels of monocyte chemoattractant protein-1 (MCP-1) in the aqueous humor of patients with acute primary angle-closure glaucoma (APACG),and its correlation with the patients' prognosis after trabeculectomy.Methods This retrospective case-control study included 19 patients with APACG who experienced a failed trabeculectomy (case group) and 57 age-and sex-matched patients with APAGG who underwent successful trabeculectomy (control group).Aqueous humor was collected before trabeculectomy for the detection of MCP-1 levels in the both groups by enzyme-linked immunosorbent assay.And finally,logistic regression analysis was applied to assess the risk factors for failed trabeculectomy.Results The MCP-1 concentration in aqueous humor was (5688.04 ± 2099.99)ng · L-1 in the case group and (2077.57 ± 568.44)ng · L-1 in the control group,and the difference between both groups were significant (P ＜ 0.001).Logistic regression analysis revealed MCP-1 level (OR =1.005;95％ CI =1.001-1.008) and a shallow anterior chamber after surgery (OR =31.430;95％ CI =1.577-57.350) were the independent risk factors for failed trabeculectomy procedures.Conclusion MCP-1 levels in aqueous humor are higher in APACG eyes with failed trabeculectomy than those with successful one during 1-year follow-up,so MCP-1 level is considered as an independent risk factor for failed trabeculectomy.
