Clinical significance of the expression of pulmonary surfactant associated protein in bronchoalveolar lavage fluid of children with refractory Mycoplasma pneumoniae pneumonia
10.7683/xxyxyxb.2018.06.020
- VernacularTitle:难治性肺炎支原体肺炎患儿支气管肺泡灌洗液中肺表面活性物质相关蛋白的表达及其临床意义
- Author:
Rui-Fang YUAN
1
;
Shao-Qing WANG
Author Information
1. 鹤壁市人民医院儿科
- Keywords:
refractory Mycoplasma pneumoniae pneumonia;
pulmonary surfactant associated protein;
bronchoalveolar lavage fluid
- From:
Journal of Xinxiang Medical College
2018;35(6):528-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of the expression of pulmonary surfactant associated pro-tein(SP)in bronchoalveolar lavage fluid(BALF)of children with refractory Mycoplasma pneumoniae pneumonia(RMPP). Methods Thirty children with RMPP were selected from January 2015 to December 2016 in the People's Hospital of Hebi City. The lung function of the children was detected in acute and recovery stage,and bronchoalveolar lavage was performed with fiexible bronchofiberscope. The BALF was collected,and the levels of SP-A,SP-B,SP-C and SP-D in BALF were detected by enzyme linked immunosorbent assay. Results The forced expiratory volume in one second (FEV 1 ),forced vital capacity (FVC)and FEV1 / FVC in RMPP children at acute stage were (1. 34 ± 0. 23)L,(1. 75 ± 0. 28)L and (68. 25 ± 6. 21)％respectively;and they were (1. 71 ± 0. 35)L,(1. 98 ± 0. 36)L and (88. 57 ± 8. 16)％ respectively in the children at recov-ery stage. The FEV1 ,FVC and FEV 1 / FVC in RMPP children at recovery stage were significantly higher than those in the chil-dren at acute stage (t = 4. 839,3. 070,14. 859;P < 0. 05). The levels of SP-A,SP-B,SP-C and SP-D in the RMPP children at acute stage were (50. 19 ± 10. 06),(42. 95 ± 12. 42),(36. 81 ± 8. 14)and (21. 57 ± 5. 46)μg·L - 1 respectively;and they were (135. 20 ± 18. 13),(108. 42 ± 20. 33),(142. 63 ± 21. 87)and (72. 69 ± 8. 54)μg·L - 1 respectively in the children at recovery stage. The levels of SP-A,SP-B,SP-C and SP-D in BALF of RMPP children at recovery stage were significantly higher than those in the children at acute stage (t = 22. 457,15. 052,24. 837,27. 623;P < 0. 05). Conclusion The detection of SP-A,SP-B,SP-C and SP-D levels in BALF plays a guiding role in the diagnosis,disease assessment,treatment and prognosis judgment of RMPP.
