Therapeutic effect of vitamin D combined benazepril on reducing urine microalbumin in hypertensive patients
10.3969/j.issn.1008-0074.2018.03.13
- VernacularTitle:维生素D联合贝那普利降低高血压病人尿微量白蛋白的疗效
- Author:
Rong ZHOU
1
;
Dao-Quan PENG
Author Information
1. 中南大学湘雅二医院心内科
- Keywords:
Hypertension;
Albuminuria;
Vitamin D;
Benazepril
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(3):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study safety and effectiveness of vitamin D combined benazepril on patients with essential hyper-tension (EH) and positive urine microalbumin (UMA).Methods :A total of 92 EH patients with positive UMA were ran-domly divided into benazepril group (n＝44 , received benazepril 5md/d ,placebo 1 capsule/d) and combined treatment group (n＝48 , received vitamin D3 400mg/d and benazepril 5mg/d) ,both groups were treated for 12 weeks.Levels of mean arterial pressure (MAP) ,serum creatinine (SCr) and UMA were measured and compared between two groups before and after treatment .Results :Compared with before treatment ,there were significant reductions in levels of MAP and UMA in two groups after treatment , P＝0.001 all ;compared with benazepril group ,there were significant reductions in levels of MAP [ (108.45 ± 15.09) mmHg vs.(101.1 ± 15.02) mmHg] and UMA [ (52.35 ± 17.45) mg/L vs.(43.75 ± 13.29) mg/L] in combined treatment group ,P＜0.05 or ＜0.01.There was no significant difference in SCr level between two groups before and after treatment , P＞0.05 all.Conclusion : Compared with pure benazepril antihypertensive treat-ment ,vitamin D combined benazepril possesses better therapeutic effect on reducing UMA and antihypertensive effect .And it is safe without obvious damage on kidney function ,which is worth extending .
