Correlation among serum high sensitive C reactive protein , homocysteine and ischemic stroke
10.3969/j.issn.1008-0074.2018.03.09
- VernacularTitle:血清超敏C反应蛋白和同型半胱氨酸与缺血性脑卒中的相关性
- Author:
Jing-Lin CHEN
1
;
Rong-Xin LIANG
;
Han WU
;
Cai-Xia TIAN
;
Lian LI
Author Information
1. 湖北医药学院附属人民医院检验科
- Keywords:
Stroke;
C-reactive protein;
Homocysteine
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(3):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore correlation among serum levels of high sensitive C reactive protein (hsCRP) ,homocys-teine (Hcy) and severity of ischemic stroke in patients with ischemic stroke .Methods :A total of 131 patients with ischemic stroke were enrolled as stroke group .According to neurologic impairment score ,they were divided into mild group (n＝59) ,medium group (n＝41) and severe group (n＝31) ;according to infarct size ,they were divided into lacunar infarction group (n＝55) ,small infarction group (n＝46) and large infarction group (n＝30).Another 98 healthy subjects undergoing physical examination during the same period were selected as healthy control group .Serum levels of hsCRP and Hcy were measured in all groups ,and their correlation with clinic neurologic impairment degree and infarct size in patients with ische-mic stroke were analyzed .Results :Compared with healthy control group ,there were significant rise in serum levels of hsCRP and Hcy in stroke group ,P＝0.001 both .Compared with mild group ,there were significant rise in serum levels of hsCRP [ (4.43 ± 0.42) mg/L vs.(6.78 ± 1.48) mg/L vs.(9.52 ± 1.73) mg/L] and Hcy [ (17.49 ± 1.32) μmol/L vs. (22.18 ± 1.83) μmol/L vs.(26.01 ± 2.37) μmol/L] in medium group and severe group ,and those of severe group were significantly higher than those of medium group , P＝0.001 all ;compared with lacunar infarction group ,there were signif-icant rise in serum levels of hsCRP [ (4.13 ± 0.53) mg/L vs.(7.61 ± 1.47) mg/L vs.(9.49 ± 2.18 ) mg/L] and Hcy [ (18.49 ± 3.27) μmol/L vs.(22.53 ± 4.28) μmol/L vs.(27.38 ± 5.12) μmol/L] in small infarction group and large in-farction group ,and those of large infarction group were significantly higher than those of small infarction group (P＝0.001 all).Pearson correlation analysis indicated that serum serum levels of hsCRP and Hcy were significant positively correlated with clinic neurologic impairment score and infarct size in patients with ischemic stroke (r＝0.253～0.641 ,P＜0.01 all). Conclusion :Serum levels of hsCRP and Hcy are important indexes assessing severity of ischemic stroke .
