Influence of L-carnitine combined coenzyme Q10 on hsCRP,cTnI and BNP levels in patients with chro-nic heart failure
10.3969/j.issn.1008-0074.2018.02.21
- VernacularTitle:左卡尼汀联合辅酶Q10对慢性心衰患者hsCRP、cTnI及BNP水平的影响
- Author:
Zhao LIU
1
;
Zhi-Qiang WANG
;
Li-Yun ZHANG
Author Information
1. 湖北省武汉市青山区红钢城街道卫生服务中心内科
- Keywords:
Heart failure;
Levocarnitin;
Coenzyme Q
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(2):195-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence of L-carnitine combined coenzyme Q10 on levels of high sensitive C reac-tive protein(hsCRP),cardiac troponin I(cTnI)and brain natriuretic peptide(BNP)in patients with chronic heart failure(CHF).Methods:A total of 100 CHF patients were randomly and equally divided into routine treatment group(received metoprolol tartrate + losartan + spironolactone treatment)and combined treatment group(re-ceived L-carnitine + coenzyme Q10 based on routine treatment),and both groups were treated for four weeks. Levels of hsCRP,cTnI and BNP and heart function were compared between two groups before and after treatment. Results:Total effective rate of combined treatment group was significantly higher than that of routine treatment group(94.0% vs.70.0%,P=0.002).Compared with before treatment,there were significant reductions in levels of hsCRP,cTnI and BNP and left ventricular end-diastolic dimension(LVEDd),and significant rise in left ventricu-lar fractional shortening(LVFS)and left ventricular ejection fraction(LVEF)after treatment in two groups,P<0.01 all;compared with routine treatment group after treatment,there were significant reductions in levels of hsCRP[(3.44 ± 0.15)mg/L vs.(2.82 ± 0.31)mg/L],cTnI[(0.25 ± 0.03)μg/L vs.(0.17 ± 0.01)μg/L],BNP [(259 ± 34)ng/L vs.(215 ± 37)ng/L]and LVEDd[(57.9 ± 10.1)mm vs.(47.4 ± 9.2)mm],and significant rise in LVFS[(29.1 ± 4.7)% vs.(32.9 ± 8.9)%]and LVEF[(60.1 ± 9.7)% vs.(65.8 ± 4.9)%]in combined treat-ment group after treatment,P<0.05 or <0.01. Second hospitalization rate within one year of combined treatment group was significantly lower than that of routine treatment group(4.7% vs.18.6%), P=0.044.Conclusion:L-carnitine combined coenzyme Q10 can significantly reduce levels of hsCRP,cTnI and BNP,improve heart function with definite therapeutic effect and it can improve prognosis in CHD patients.
