Myocardial protection effects of atorvastatin on aged NSTEACS patients during PCI
10.3969/j.issn.1008-0074.2018.02.20
- VernacularTitle:阿托伐他汀对老年非ST段抬高型急性冠脉综合征患者PCI的心肌保护作用
- Author:
Wen XIONG
1
Author Information
1. 武汉科技大学附属孝感医院手术室
- Keywords:
Myocardial infarction;
Angioplasty;
balloon;
coronary;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(2):191-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore myocardial protection effects of different doses of atorvastatin on aged patients with non-ST elevation acute coronary syndrome(NSTEACS)during percutaneous coronary intervention(PCI).Methods:A total of 92 aged NSTEACS patients undergoing selective PCI in our hospital were selected.They were randomly and equally divided into standard dose group(received atorvastatin 20mg/time,once a day for 3d before PCI)and large dose group(received atorvastatin 40mg/time,once a day for 3d before PCI).Both groups all received routine treatment before PCI.Levels of cardiac troponin I(cTnI)and creatine kinase isoenzyme MB(CK-MB),high sensi-tive C reactive protein(hsCRP),interleukin-6(IL-6)and soluble intercellular adhesion molecule-1(sICAM-1)be-fore and after PCI,and incidence rate of adverse cardiac events were observed and compared between two groups. Results:Compared with before PCI,there were significant rise in levels of cTnI,CK-MB,hsCRP,IL-6 and sI-CAM-1 in two groups after PCI,P=0.001 all.Compared with standard dose group after PCI,there were signifi-cant reductions in levels of cTnI[(1.93 ± 0.35)ng/ml vs.(1.54 ± 0.32)ng/ml],CK-MB[(2.79 ± 0.52)ng/ml vs.(2.31 ± 0.46)ng/ml],hsCRP[(18.54 ± 3.50)mg/L vs.(15.67 ± 3.22)mg/L],IL-6[(35.59 ± 6.47)ng/ml vs. (32.41 ± 6.54)ng/ml]and sICAM-1[(329.76 ± 54.18)μg/L vs.(305.35 ± 54.24)μg/L];incidence rate of ad-verse cardiac events(4.35% vs.21.74%,P=0.03)in large dose group,P<0.05 or <0.01;Conclusion:Com-pared with preoperative 20mg atorvastatin therapy,40mg atorvastatin therapy before PCI possesses more significant anti-inflammation and myocardial protection effect,and can significantly reduce postoperative incidence rate of ad-verse cardiac events in aged NSTEACS patients.
