Influence of preoperative nicorandil application on coronary no-reflow in patients with acute anterior myocardial infarction
10.3969/j.issn.1008-0074.2018.02.12
- VernacularTitle:急性前壁心肌梗死术前应用尼可地尔对冠脉无复流影响的研究
- Author:
Da-Peng LI
1
;
Gui-Xia ZHANG
;
Ming-Liang ZHANG
;
Huan-Yu WANG
;
Zhi LI
;
Ting-Ting LI
Author Information
1. 佳木斯市中心医院心内科
- Keywords:
Myocardial infarction;
Angioplasty;
balloon;
coronary;
No-reflow phenomenon;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence of preoperative nicorandil application on coronary no-reflow during emer-gency percutaneous coronary intervention(PCI)in patients with acute anterior myocardial infarction(AAMI). Methods:A total of 116 AAMI patients were randomly and equally divided into routine treatment group and nic-orandil group(received nicorandil based on routine treatment).TIMI grade,incidence rate of no-reflow,ECG ST-segment elevation resolution(STR)and incidence rate of major adverse cardiovascular events(MACE)after PCI were compared between two groups.Results:Compared with routine treatment group after PCI,there were signifi-cant rise in percentage of infarct related artery(IRA)TIMI grade 3(77.6% vs.91.4%)and STR on 2h after PCI[(0.15 ± 0.05)mm vs.(0.18 ± 0.05)mm],and significant reductions in incidence rates of no-reflow(13.8% vs. 3.4%)and MACE(17.2% vs.5.2%)in nicorandil group after PCI,P<0.05 or <0.01. Conclusion:Preoperative nicorandil application can reduce incidence rate of no-reflow after PCI,improve myocardial perfusion and reduce in-cidence rate of major adverse cardiovascular events.
