Correlation among serum levels of P-selectin,high sensitive C reactive protein and chitinase protein-40 in patients with acute coronary syndrome
10.3969/j.issn.1008-0074.2018.02.08
- VernacularTitle:急性冠脉综合征患者血清甲壳质酶蛋白-40与P选择素及hsCRP水平的相关性
- Author:
Hong-Yu YANG
1
;
Xiao-Hui ZHAO
;
Xiu-Yan WANG
;
Jun YANG
Author Information
1. 佳木斯大学附属第一医院心内科
- Keywords:
Acute coronary syndrome;
P-Selectin;
C-reactive protein
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(2):146-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore changes of serum levels of chitinase protein-40(YKL-40),P-selectin and high sensi-tive C reactive protein(hsCRP)in patients with acute coronary syndrome(ACS)and their correlation.Methods:A total of 160 patients with coronary heart disease(CHD),including 80 ACS cases and 80 cases with stable angina pec-toris(SAP),were selected.Another 80 non-CHD patients were enrolled as normal control group.Serum levels of YKL-40,P-selectin and hsCRP were measured by enzyme linked immunosorbent assay and compared among all groups.Results:Compared with normal control group and SAP group,there were significant rise in serum levels of YKL-40[(20.92 ± 3.19)ng/ml vs.(45.18 ± 3.96)ng/ml vs.(61.84 ± 3.51)ng/ml],P-selectin[(65.01 ± 16.18) μg/L vs.(97.58 ± 31.43)μg/L vs.(137.41 ± 48.26)μg/L]and hsCRP[(6.91 ± 3.68)mg/L vs.(8.32 ± 4.21) mg/L vs.(30.01 ± 11.05)mg/L]in ACS group,P=0.001 all.Linear correlation analysis indicated that serum P-selectin and hsCRP levels was significant positively correlated with serum YKL-40 level(r= 0.46,0.041, P=0.021,0.015).Conclusion:Serum levels of YKL-40,P-selectin and hsCRP significantly rise in ACS patients,sug-gesting that these indexes are related to atherosclerotic plaque instability,which can be used as serological indexes judging atherosclerotic plaque instability.
