Influence of pitavastatin on vascular endothelial function in young and middle-aged patients with hyperlipidemia complicated carotid plaques
10.3969/j.issn.1008-0074.2018.01.09
- VernacularTitle:匹伐他汀对中青年高脂血症合并颈动脉斑块患者血管内皮功能的影响
- Author:
Xiao-Na ZHAN
1
;
Gui-Hua LI
;
Ya-Juan WANG
;
Li-Juan FU
;
Lei GAO
Author Information
1. 北京市垂杨柳医院心脏中心
- Keywords:
Hyperlipidemias;
Carotid artery thrombosis;
Endothelium;
Pitavastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore therapeutic effect of pitavastatin on young and middle-aged patients with hyperlipidemia complicated carotid plaques and its influence on vascular endothelial function. Methods: A total of 126 young and middle-aged patients with hyperlipidemia complicated carotid plaques [carotid intima-media thickness (IMT) ＞ 1. 5mm]were selected, and were randomly divided into no lipid lowering treatment group (n=62) and pitavastatin group (n=64). Flow-mediated dilation of brachial artery (FMD), carotid IMT and blood lipid levels before and 12 months after medication, and incidence rate of adverse events were recorded and compared between two groups. Results: Compare with before treatment and no lipid lowering treatment group after treatment, there was significant rise in FMD [(6. 70±2. 10) ％, (6. 60±2. 35) ％ vs. (8. 90±3. 60) ％], and significant reductions in levels of total cholesterol [(6. 05±1. 40) mmol/L, (5. 67±1. 90) mmol/L vs. (4. 05±1. 20) mmol/L], triglyceride [(2. 18± 0. 72) mmol/L, (2. 08±0. 68) mmol/L vs. (1. 77±0. 65) mmol/L]and low density lipoprotein cholesterol [(4. 65±1. 50) mmol/L, (4. 41±1. 36) mmol/L vs. (2. 01±1. 30) mmol/L]in pitavastatin group, P＜0. 05 or＜0. 01; there were no significant changes in IMT in two groups. No obvious adverse reaction was found in pitavastatin group. Conclusion: Pitavastatin can significantly improve lipid levels and vascular endothelial function in young and middle-aged patients with hyperlipidemia complicated carotid plaques.
