Predictive value of NT-proBNP combined Lp (a) detection for coronary in-stent restenosis
10.3969/j.issn.1008-0074.2018.01.06
- VernacularTitle:联合检测NT-proBNP、Lp(a)对冠脉支架内再狭窄的预测价值
- Author:
Zhongyu GUO
1
;
Tie-Bing ZHU
;
Yong TANG
Author Information
1. 东南大学附属第二医院心内科
- Keywords:
Coronary stenosis;
Drug-eluting stents;
Natriuretic peptide;
brain;
Lipoprotein(a)
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship among levels of N terminal pro brain natriuretic peptide (NT-proBNP), lipoprotein (a) [Lp (a)] and in-stent restenosis (ISR) in patients after stent implantation. Methods: A total of 625 pa-tients, who received drug-eluting stent implantation in our department and underwent coronary angiography one year after surgery, were continuously collected. According to presence of ISR or not, patients were divided into no restenosis group (n=532) and ISR group (n=93). Plasma levels of NT-proBNP and Lp (a) were measured and compared between two groups. Single-factor and multi-factor Logistic regression analysis were used to analyze the relationship among levels of NTproBNP, Lp (a) and coronary ISR. Results: Compared with no restenosis group, there were significant rise in plasma levels of NT-proBNP [(749. 43±154. 82) ng/L vs. (856. 12±132. 45) ng/L]and Lp (a) [(299. 23±29. 07) mg/L vs. (321. 12±31. 05) mg/L]in ISR group, P=0. 001 both; multi-factor Logistic analysis indicated that plasma levels of NTproBNP (OR=2. 162, 95％CI 2. 002～2. 333) and Lp (a) (OR=2. 903, 95％CI 2. 648～3. 184) were independent risk factors for ISR, P＜0. 05 both. Conclusion: N terminal pro brain natriuretic peptide and lipoprotein (a) are independent risk factors for in-stent restenosis in patients undergoing stent implantation.
