Risk factors of acute bilirubin encephalopathy in neonates with severe hyperbilirubinemia
10.3760/cma.j.issn.2096-2932.2018.06.006
- VernacularTitle:严重新生儿高胆红素血症并发急性胆红素脑病高危因素分析
- Author:
Yuanli ZHAN
1
;
Haibo PENG
;
Min ZHANG
;
Xiaoqin LIANG
;
You CHEN
Author Information
1. 518101,深圳市宝安区妇幼保健院新生儿科
- Keywords:
Hyperbilirubinemia,neonatal;
Risk factors;
Acute bilirubin encephalopathy
- From:Chinese Journal of Neonatology
2018;33(6):423-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors of acute bilirubin encephalopathy (ABE) in neonates with severe hyperbilirubinemia (total serum bilirubin ≥ 427.5 μmol/L).Method Clinical information of neonates with severe hyperbilirubinemia admitted to the Neonatal Department of Baoan Maternal and Child Health Hospital in Shenzhen from December 2013 to October 2017 were collected.The enrolled cases were grouped as ABE and the control group (without ABE).The risk factors for ABE were compared between the two groups and the Logistic regression analysis was used to evaluate the independent risk factor.Result A total of 104 neonates were recruited.There were 32 cases in the ABE group and 72 cases in the control group.The level of total serum bilirubin and indirect bilirubin,the ratio of total bilirubin/albumin,the incidence of glucose-6-phosphate dehydrogenase deficiency and metabolic acidosis and sepsis,the rate of using traditional Chinese medicine and the failure of treatment in other hospitals and non-resident population were all significantly higher in the ABE group than the control (P ＜ 0.05).Logistic regression analysis showed that total serum bilirubin (OR =1.013,95％ CI 1.007 ～ 1.020) and sepsis (OR =6.343,95％ CI 1.801 ～22.338) were the independent risk factors for ABE.Conclusion The severe hyperbilirubinemia infants,particularly with sepsis,are at higher risk of developing acute bilirubin encephalopathy.
