The correlation analysis between vascular endothelial growth factor gene polymorphism (－460T＞C) and bronchopulmonary dysplasia
10.3760/cma.j.issn.2096-2932.2018.04.001
- VernacularTitle:血管内皮生长因子基因－460T＞C位点多态性与支气管肺发育不良的相关性分析
- Author:
Qiaoyan DU
1
;
Hua MEI
;
Yuheng ZHANG
;
Chun XIN
;
Xin JIA
Author Information
1. 内蒙古医科大学附属医院新生儿科
- Keywords:
Bronchopulmonary dysplasia;
Vascular endothelial growth factors;
Genetic testing;
Polymorphism,single nucleotide;
Infant,premature
- From:Chinese Journal of Neonatology
2018;33(4):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the polymorphism of vascular endothelial growth factor ( VEGF) gene－460T ＞C locus and its correlation with bronchopulmonary dysplasia ( BPD ) in preterm infants. Method From October 2014 to October 2017, a prospective study was conducted on BPD preterm infants admitted to the neonatal department of the Affiliated Hospital of Inner Mongolia Medical University .During the same time, non-BPD preterm infants of the same nation and same ethnic group were selected as the control group.The ratio between the BPD group and the control group was 1∶1.Genotype and allelic distribution of VEGF－460T＞C loci in both groups were detected using polymerase chain reaction method . Result A total of 100 BPD infants were enrolled in the BPD group , including 50 cases of Mongolian nationality and 50 cases of Han nationality.Both TT and CT genotypes were detected in the VEGF －460T＞C locus in the BPD and control groups .The frequencies of the two genotypes were 38.0%and 62.0%in the BPD group, 29.0% and 71.0% in the control group.The C allele frequencies were 31.0% in the BPD group and 35.5%in the control group.The T allele frequencies were 69.0%in the BPD group and 64.5%in the control group.No significant differences existed in allele and genotype frequencies between the two groups (P＝0.178 and 0.338).The frequencies of the two genotypes in the Mongolian BPD infants and the Han BPD infants were 40.0%and 60.0%vs.36.0%and 64.0%.The C allele frequencies were 30.0%and 32.0%, and the T allele frequencies were 70.0% and 68.0%.No significant differences existed in allele and genotype frequencies between the two groups ( P ＝0.680 and 0.648 ) .Conclusion No correlation existed between the polymorphism of VEGF －460T＞C locus and the occurrence and development of BPD in premature infants in Inner Mongolia.
