Change and significance of serum inflammatory cytokines and pulmonary surface proteins in respiratory failure of full-term infants
10.3760/cma.j.issn.2096-2932.2018.03.008
- VernacularTitle:血清炎症细胞因子和肺表面活性蛋白在足月儿呼吸衰竭中的变化及意义
- Author:
Chong CHEN
1
,
2
;
Ming CHI
;
Shaodong HUA
;
Jia CHEN
;
Ling TANG
;
Zhichun FENG
Author Information
1. 100700 第二军医大学陆军总医院临床医学院附属八一儿童医院NICU
2. 解放军总医院第一附属医院儿科
- Keywords:
Respiratory insufficiency;
Cytokines;
Acute respiratory distress syndrome;
Alveolar surface protein
- From:Chinese Journal of Neonatology
2018;33(3):191-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes and significance of inflammatory cytokines and pulmonary surface protein (SP) level in respiratory failure of full-term infants.Method Prospectively selected 30 cases of term baby with respiratory failure requiring mechanical ventilation and pulmonary surfactant (PS) treatment in BaYi Children's Hospital from May 2016 to January 2017 as case group,while 30 cases of term baby with transient tachypnea or hypoglycemia were control group.Blood samples were collected at the first and third day of hospitalization.The interleukin-6 (IL-6),IL-10,and tumor necrosis factor-α (TNF-α) were detected by flow cytometry,serum SPs were detected by enzyme-linked immunosorbent assay method.The statistical analyses were conducted by SPSS 22.0 software.Result The levels of IL-6,IL-10,SP-A,SP-B and SP-C in the case group were significantly higher than those in the control group [IL-6:172.4 (58.4,668.4) ng/L vs.8.3 (5.7,11.2) ng/L,IL-10:10.2 (5.9,31.5) ng/L vs.4.7 (3.6,7.1) ng/L,SP-A:6.94 (2.37,29.64) μg/L vs.0.56 (0.50,0.64) μg/L,SP-B:4.36 (1.99,5.25)μg/L vs.1.44 (1.25,1.79) μg/L,SP-C:0.87 (0.19,2.66) μg/L vs.0.14 (0.10,0.16) μg/L,P ＜0.05].After exogenous PS treatment,serum SP-A,SP-B,SP-C,IL-6 and IL-10 levels in the surviving group were significantly lower comparing with the first day (P ＜ 0.05).The IL-6,SP-A and SP-C levels in the first day death group were significantly higher than those in survival group(P ＜ 0.05).Conclusion Inrespiratory failure of full-term infants,serum IL-6 levels are consistent with the SP-A and SP-C levels,and a sustained increase may serve as a potential early biomarker for disease progression.
