Multi-center retrospective clinical survey of neonatal purulent meningitis in china
10.3760/cma.j.issn.2096-2932.2018.01.002
- VernacularTitle:新生儿化脓性脑膜炎诊疗现状和预后的多中心调查研究
- Author:
Zhi ZHAO
1
,
2
;
Xueying HUA
;
Haibo ZHANG
;
Jialin YU
;
Pengjiang KANG
;
Juhua LI
;
Zhankui LI
Author Information
1. 710068 西安,陕西省人民医院新生儿科
2. 400014 重庆医科大学附属儿童医院新生儿诊疗中心,儿童发育疾病研究教育部重点实验室
- Keywords:
Meningitis,bacterial;
Epidemiology;
Multicenter study;
Infant,newborn
- From:Chinese Journal of Neonatology
2018;33(1):2-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics,diagnosis and clinical outcomes of neonatal purulent meningitis in southwest and northwest regions of China.Method There were 5 tertiary hospitals in southwest and northwest regions of China with well capacity of treating neonatal diseases collaborated as the neonatal meningitis network.From January 2010 to December 2014,clinical symptoms,signs and outcomes of cases with the diagnosis of neonatal meningitis were retrospectively studied.Result During the study period,a total of 63 514 neonates were admitted to 5 neonatal departments in Chongqing and Shanxi Province,China,and 407 cases were diagnosed of bacterial meningitis.255 (62.7％) cases were males.The mean gestational age was (37.1 ±3.2) weeks.125 (30.7％) were preterm infants and69 late-preterm infants.The mean birth weight was (2 859 ± 771) g,90 (22.1％) cases were low birth weight infant.The incidence of neonatal purulent meningitis were 0.64％ (From 2010 to 2014,0.30％,0.72％,0.64％,0.89％ and 1.12％ respectively),and 77.6％ of the cases were the late-onset infection.The mortality rate were 9.1％ (From 2010 to 2014,6.3％,4.0％,9.8％,8.4％ and 8.5％ respectively).The incidence of neurological sequelae was 5.9％ (From 2010 to 2014,12.5％,8.0％,6.1％,6.3％ and 11.6％ respectively).The mean duration of hospital stay was 21 days.Mean duration of antibiotic treatment was 19 days.The remission rate was 85.0％ (346/407).Conclusion From 2010 to 2014,on average,the incidence of neonatal purulent meningitis was 0.64％,mortality rate was 9.1％,neurological sequelae was 5.9％,and remission rate was 85.0％.Among these years the mortality and neurological sequelae of neonatal purulent meningitis were not decreasing.
