A Case of Toenail Onychomycosis Due to Aspergillus sydowii Infection.
10.17966/KJMM.2015.20.1.6
- Author:
You Bum SONG
1
;
Jun Gyu SONG
;
Moo Kyu SUH
;
Gyoung Yim HA
;
Jin Hwa CHOI
Author Information
1. Department of Dermatology, College of Medicine, Dongguk University, Gyeongju, Korea. smg@dongguk.ac.kr
- Publication Type:Case Report
- Keywords:
Aspergillus sydowii;
Toenail onychomycosis
- MeSH:
Agar;
Aged;
Arthrodermataceae;
Aspergillus*;
Base Sequence;
Fungi;
Glucose;
Humans;
Hyphae;
Lacquer;
Male;
Nails*;
Onychomycosis*;
Penicillium;
Potassium;
Sequence Analysis, DNA;
Yeasts
- From:Korean Journal of Medical Mycology
2015;20(1):6-12
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Onychomycosis is caused by dermatophytes usually, but some species of nondermatophytic molds and yeasts are also associated with invasion of nails. Aspergillus sydowii is a nondermatophytic mold which is opportunistic filamentous fungus in all environments. We report a case of onychomycosis caused by A. sydowii in a 65-year-old male. The patient showed yellowish discoloration with hyperkeratotic change on the distal and lateral portion of both great toenails. Direct microscopic examination of scraping on the potassium hydroxide preparation revealed dichotomous septate hyphae and repeated cultures on Sabouraud dextrose agar showed the same blue green velvety colonies. Biseriate phialides that cover entire vesicle with conidial structure resembling Penicillium were shown in the slide culture. The DNA sequence of internal transcribed spacer (ITS) region of clinical sample was 99% match to that of A. sydowii strain XWSFJJ1 (GenBank accession number FJ461692). We confirmed A. sydowii by KOH mount, colony, light microscopic morphology and DNA sequence analysis. The patient was treated with 250 mg oral terbinafine daily and topical 5% amorolfine nail lacquer for 3 months.
