Application of the exosome in diagnosis and treatment of digestive system cancers
10.3760/cma.j.issn.1673-9752.2018.04.003
- VernacularTitle:外泌体在消化系统肿瘤精准诊断与治疗中的应用
- Author:
Lunxiu QIN
1
;
Haoting SUN
;
Chaoqun WANG
Author Information
1. 复旦大学附属华山医院普通外科复旦大学肿瘤转移研究所
- Keywords:
Digestive system neoplasms;
Precision medicine;
Translational medicine;
Exosome;
Diagnosis;
Therapy
- From:
Chinese Journal of Digestive Surgery
2018;17(4):333-337
- CountryChina
- Language:Chinese
-
Abstract:
The concept of precision medicine and precision oncology has been widely accepted.However,the application of this concept still faces many challenges.Exosome investigation is a hot spot in the field of liquid biopsy.Exosomes are extracellular vesicles composed of a lipid bilayer and contain proteins and nucleic acids which regulate cell-cell communication.Exosomes can be isolated and enriched in various body fluids.It has the advantages of micro-invasive,stable and biological active,and it fits well with the practice of precision medicine.In this review,authors discussed potential application and challenge of exosomes in early diagnosis and metastasis monitoring of gastric cancer.
