Application of leukoreduction therapy in severe pertussis with leukocytosis and pulmonary hyperten-sion:3 infant cases reports and literatures review
10.3760/cma.j.issn.1673-4912.2018.11.001
- VernacularTitle:白细胞去除术治疗婴儿高白细胞合并肺动脉高压百日咳三例并文献复习
- Author:
Long XIANG
1
;
Qing CAO
;
Yueling XI
;
Hong REN
;
Jian ZHANG
;
Changying LUO
;
Juan QIAN
;
Ying WANG
;
Biru LI
Author Information
1. 200127,上海交通大学医学院附属上海儿童医学中心重症医学科
- Keywords:
Severe pertussis;
Leukocytosis;
Pulmonary hypertension;
Leukoreduction;
Leukopheresis;
Exchange transfusion
- From:
Chinese Pediatric Emergency Medicine
2018;25(11):801-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of leukoreduction therapy in severe per-tussis in infants. Methods Therapeutic processes of 3 cases of severe pertussis in PICU of Shanghai Children′s Medical Center were retrospectively studied from October 2017 to May 2018. We reviewed the related literatures and summarized the time and effectiveness of leukoreduction therapy in severe pertussis. Results All 3 cases had leukocytosis,respiratory faliure,pulmonary hypertension and right heart failure. One case had multiple organ failure before undergoing exchange transfusion therapy and eventually died. Two cases that had pulmonary hypertension during the period of WBC′s rising accepted leukopheresis therapy before multiple organ failure,and eventually survived. We reviewed the foreign literatures which was almost case reports,leukoreduction therapy might improve the prognosis of severe pertussis in infants,but the time of using it had no conclusion. Conclusion This is the first report of leukoreduction therapy for the severe per-tussis in infants in China. It provides a new method for the treatment of severe pertussis in infants. It is worth looking forward to use this method combined with continuous renal replacement therapy and extracorporeal membrane oxygenation technology. In the future,multicenter clinical research should be done to explore the effectiveness and safety of leukoreduction therapy in the severe pertussis in infants.
