Clinical syndrome of dystonia-parkinsonism.
- Author:
Yong Duk KIM
1
;
Myung Sik LEE
;
Jae Hyeon PARK
;
Dae Il CHANG
Author Information
1. Department of Neurology, Yongdong Severance Hospital, Korea.
- Publication Type:Original Article
- MeSH:
Dystonia;
Foot;
Functional Neuroimaging;
Hand;
Humans;
Levodopa;
Neck;
Parkinson Disease
- From:Journal of the Korean Neurological Association
1997;15(2):286-299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report 11 patients who developed dystonia and parkinsonian symptoms and signs. All of them developed the onset of parkinsonian symptoms 1 month to about 50 years(median: 2 yrs) after the onset of dystonia. Six of 11 patients developed dystonia affecting a hand; two affecting a foot; one affecting the neck; one affecting bilateral hands and a foot; one affecting a foot, trunk and neck Their parkinsonian symptoms had progressed very slowly and responded well to the levodopa treatment. Beside, none of them had clinical features suggestive of parkinsonian-plus syndrome. These findings suggest that they may have pathological changes confined to the nigrostriatal dopaminergic system as those with idiopathic Parkinson's disease. However, no change or worsening of dystonia after levodopa treatment suggest that they may have additional lesions out-side of the nigrostriatal dopaminergic system. More pathological studies and functional brain imaging studies are needed to define the exact pathogenesis of clinical syndrome of dystonia-parkinsonism.
