The diagnostic value of cerebrospinal fluid protein in the assessment of neurological outcome in preterm infants with sepsis
10.3760/cma.j.issn.1673-4912.2018.10.002
- VernacularTitle:脑脊液蛋白在评估败血症早产儿神经系统预后中的诊断价值
- Author:
Na LI
1
;
Xiaohui GONG
;
Gang QIU
;
Li MA
;
Hao CHEN
;
Yihuan CHEN
;
Chongbing YAN
Author Information
1. 200062,上海市儿童医院 上海交通大学附属儿童医院新生儿科
- Keywords:
Sepsis;
Preterm infants;
Cerebrospinal fluid protein;
Gesell Developmental Schedules;
Neurodevelopment outcome
- From:
Chinese Pediatric Emergency Medicine
2018;25(10):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of cerebrospinal fluid protein in the assess-ment of neurological outcome in preterm infants with sepsis. Methods A total of 80 preterm infants with sepsis were enrolled in the department of neonatology of Shanghai Children's Hospital from June 2014 to June 2016. The lumbar puncture was completed within 24 hours after diagnosis of sepsis,and the results of ce-rebrospinal fluid protein were obtained. The prognosis of neurological development was assessed according to Gesell Developmental Quotient ( DQ) at 6 months of adjusted gestational age. DQ> 85 was used as an indi-cator of good prognosis group. DQ≤85 was assigned to the poor prognosis group. The differences in protein content of cerebrospinal fluid between these two groups were retrospectively analyzed. The receiver operating characteristic ( ROC) curve was used to evaluate the diagnostic value of cerebrospinal fluid in evaluating the prognosis of preterm infants with sepsis. Results Cerebrospinal fluid protein content of poor prognosis group was higher than those in good prognosis group[(2005. 56 ± 582. 85)mg/L vs. (1367. 92 ± 362. 29)mg/L, t= -6. 019,P<0. 01]. The area under the ROC curve was 0. 819(95％CI 0. 711 -0. 927,P<0. 05). The optimal threshold of cerebrospinal fluid protein was 1560 mg/L with specificity of 75. 5％ and sensitivity of 81. 5％. Conclusion Cerebrospinal fluid protein content has certain diagnostic value on the assessment of sepsis premature neurological prognosis.
