Research progress of high mobility group box 1 in pediatric diseases
10.3760/cma.j.issn.1673-4912.2018.09.011
- VernacularTitle:高迁移率族蛋白B1在儿科疾病中的研究进展
- Author:
Xuemei YANG
1
;
Xirong GAO
;
Yunqin WU
Author Information
1. 南华大学儿科学院
- Keywords:
High mobility group box 1 protein;
Biological characteristics;
Pediatrics;
Inflammation
- From:
Chinese Pediatric Emergency Medicine
2018;25(9):691-694
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 protein(HMGB1) is widely present in eukaryotic nuclei and named for its rapid migration during polyacrylamide gel electrophoresis. Studies have shown that HMGB1 playes an important role in the development of gene transcription,inflammation,cancer and other diseases. In this paper, the biological characteristics of HMGB1 and its research progress in pediatric diseases are reviewed.
