Analysis of intracranial infection induced by Acinetobacter baumannii in children
10.3760/cma.j.issn.1673-4912.2018.06.012
- VernacularTitle:儿童鲍曼不动杆菌所致颅内感染的临床分析
- Author:
Yu ZHANG
1
;
Weichun HUANG
;
Hui YU
;
Ting ZHANG
;
Chunzhen HUA
;
Qing CAO
Author Information
1. 200127上海交通大学医学院附属上海儿童医学中心感染科
- Keywords:
Acinetobacter baumannii;
Bacterial meningitis;
Cerebrospinal fluid;
Children;
Clinical analysis
- From:
Chinese Pediatric Emergency Medicine
2018;25(6):450-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence of Acinetobacter baumannii induced paediatric bacterial meningitis and to explore the characteristics,treatment,and prognosis of Acinetobacter baumannii menin-gitis. Methods The cerebrospinal fluid specimens and the clinical data about patients who acquired intracranial infection of Acinetobacter baumannii were collected from 10 children′s hospital,and analysed by WHONET. Results A total of 318 positive cerebrospinal fluid specimens from 10 hospitals were collected,and 16(5%) of Acinetobacter baumannii were detected. Acinetobacter baumannii was completely resistant to Aztreonam (100%),Cefotetan(100%) and Cefazolin(100%),and the resistance rates of Acinetobacter baumannii to Ceftriaxone and Ciprofloxacin were above 80%,and the resistance rates of Acinetobacter baumannii to Cefta-zidime and Cefepime were all 68. 8%,and the resistance rates of Acinetobacter baumannii to Meropenem, Imipenem,Cefoperazone/Sulbactam were 69. 2%,68. 8% and 53. 3%,respectively. In 16 cases of intracrani-al infection caused by Acinetobacter baumannii,11 cases(68. 8%) had underlying diseases such as intracrani-al tumor,hydrocephalus,craniocerebral injury and intracranial hemorrhage,and all 11 cases underwent surgi-cal intervention,such as surgical resection and hydrocephalus drainage. Among 16 cases,14 cases(87. 5%) were admitted to SICU,PICU or NICU and other intensive care units,and the lengths of stay were all ＞20 d. Under the combined treatment of multiple antibiotics,16 cases of intracranial infection caused by Acinetobact-er baumannii,6 cases died,with a mortality of 37. 5%. Conclusion Acinetobacter baumannii meningitis is becoming an increasingly common clinical entity recently. Because of the resistance to antibiotics,the therapy for Acinetobacter baumannii infection encounters arduous challenge. Insisting on multi-center monitoring and using antibiotics reasonably and effectively appears to be particularly important.
