Progress on mesenchymal stem cells in the treatment of bronchopulmonary dysplasia

VernacularTitle:间充质干细胞治疗支气管肺发育不良的研究进展
Author: Yi YANG ^{1
,

2} ; Xinghui ZHENG
Author Information

1. 563000 遵义医学院研究生学院
2. 563000 遵义医学院第三附属医院新生儿科
Keywords: Bronchopulmonary dysplasia; Stem cell transplantation; Mesenchymal stem cell; Infant; Premature infant
From: Chinese Pediatric Emergency Medicine 2018;25(5):390-394
CountryChina
Language:Chinese
Abstract: Although some progress has been made in neonatal intensive care units for bronchopulmo-nary dysplasia ( BPD) ,a chronic lung disease threatening the premature,it is still the main cause of premature death and long-term illness. There is no effective treatment or prevention strategy for BPD. In recent years,ac-cording to researches,it′s suggested that mesenchymal stem cell therapy may reduce the severity of BPD, which is a new strategy for the treatment of BPD. The review summarized the latest advances on stem cell therapy for BPD. In this regard,it focused on preclinical data of using stem cell transplantation to improve the lung injury in neonatal BPD animal models. These studies provided data and safety issues of the best stem cell types,the best time,transplantation object,transplantation path and dose. In addition,it also discussed successful phaseⅠclinical trial results of BPD stem cells therapy,and the follow-up condition in the next 2 years.