Study on the Inhibitory Effect and Mechanism of Guizhi Fuling Pill on Angiogenesis in Rats with Endometriosis
10.3969/j.issn.1671-332X.2018.05.031
- VernacularTitle:桂枝茯苓丸对大鼠子宫内膜异位症血管生成的抑制作用及机制研究
- Author:
Lipeng LIN
1
;
Zebin LIU
;
Xiaobin WU
Author Information
1. 深圳市福田区妇幼保健院 广东 深圳 518026
- Keywords:
Endometriosis;
Guizhi Fuling Pill;
Mechanism of Action;
Inhibition
- From:Modern Hospital
2018;18(5):725-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and discuss the specific effect and mechanism of Guizhi Fuling pill on angiogenesis in rats with endometriosis. Methods A rat model of endometriosis was established in 40 rats in the same batch, they were randomly divided into 4 groups. The model control group did not give any drugs; the low dose of Guizhi Fuling pill group was given 0. 5 g Guizhi Fuling pill every day; the high dose of Guizhi Fuling pill group was given 3. 0 g cinnamon Fuling pill every day; gestation three ketone group was given three ketene 2 g every day. After 4 weeks of continuous administration, the rats were killed and the expression of VEGF and HIF-1 alpha in the rats was determined. The mechanism of Guizhi Fuling pill in the treatment of endometriosis was determined through the expression of VEGF and HIF-1α. Results Guizhi Fuling pill significantly inhibited the level of intravascular VEGF in rat endometriosis and inhibited the level of mRNA expression of HIF-1α. Conclusion Guizhi Fuling pill can inhibit the angiogenesis of endometriosis, and its mechanism is related to the inhibition of VEGF and HIF-1 alpha.
