Tissue-engineered cartilage implantation for the treatment of full-thickness knee cartilage defects
10.3969/j.issn.2095-4344.0745
- VernacularTitle:组织工程化软骨细胞移植修复膝关节大面积全层软骨缺损
- Author:
Wen-Zhe FENG
1
;
Wei LU
;
Jian XU
;
Wei-Min ZHU
;
Kan OUYANG
;
Liang-Quan PENG
;
Hai-Feng LIU
;
Hao LI
;
Kang CHEN
;
Ying LI
Author Information
1. 深圳市第二人民医院运动医学科
- From:
Chinese Journal of Tissue Engineering Research
2018;22(14):2152-2156
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The use of normal hyaline cartilage to repair large areas of full-thickness knee cartilage defect has been a hot topic recently; however, a follow-up study with a relative large number of patients is required. OBJECTIVE:To make a preliminary study concerning the methods and therapeutic effects of tissue-engineered cartilage (TEC) implantation for treating large-area full-thickness knee cartilage defects. METHODS:Twenty-one patients (23 knees) diagnosed with cartilage defect of the knee joint (Outbridge III-IV) were enrolled. The area of the cartilage defect was 3.5-11.2 cm2. All of the patients were given TEC treatment. Postoperative functional exercise of the knee joint was carried out in these patients as planned. We regularly reviewed the knee MRI and calculated visual analog scale score, International Knee Documentation Committee (IKDC) score, and Lysholm score. RESULTS AND CONCLUSION:All the patients were followed up for 3 to 12 months. Postoperatively knee pain relieved obviously, and the visual analog scale score was significantly declined compared with the preoperation (P<0.05). All the patients manifested painless 1 year after surgery. The 1-year postoperative MRI showed that the injured cartilage grew well. The thickness and MRI signal of the graft was the same as the normal cartilage, and the bone healed completely. The IKDC and Lysholm scores were significantly improved at 3, 6, 12 months after the surgery, and the difference was statistically significant before and after the surgery (P<0.05). Overall, TEC is an improved technique of chondrocyte implantation, which is an effective and safe method for cartilage defect repair.
