Protective effects of probiotics on the cell membrane in different tissues of rats after treadmill exercise
10.3969/j.issn.2095-4344.0206
- VernacularTitle:跑台运动和益生菌干预对大鼠不同组织细胞膜的保护作用
- Author:
Wei-Bin MO
1
;
Yan ZHOU
;
Yan-Tao YANG
Author Information
1. 广西师范大学体育学院
- From:
Chinese Journal of Tissue Engineering Research
2018;22(12):1877-1882
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Changes in the immune function of different tissues after long-time exhaustive exercise stress and probiotics intervention are still unclear. OBJECTIVE: To observe the morphological changes and cell membrane protective effects of different tissues and organs in rats after exhaustive exercise and probiotics intervention. METHODS: Forty Sprague-Dawley male rats were randomly allocated into quiet control group, exercise control group, quiet administration group and exercise administration group. Rats in the exercise control and exercise administration groups underwent 6 weeks of exhaustive training, at a speed of 19.3 m/min, slope of 5o, once daily, 6 days weekly. Rats in the quiet administration and exercise administration groups were given 107CFU/mL probiotics via gavage,10.0 mL/(kg?d).The histopathological changes were observed under light microscope and Na+/K+-ATPase, Ca2+/Mg2+-ATPase and T-ATPase in the liver, intestine and stomach were tested after 6 weeks of training. RESULTS AND CONCLUSION: After exhaustive exercise, the liver, stomach and intestinal tissue presented with structure disorders, swelling and inflammatory cell infiltration and an decrease in the activity of Na+/K+-ATPase, Ca2+/Mg2+-ATPase and T-ATPase. After probiotic solution administrated, the structure of liver, stomach and intestine arranged closely and clearly, with no obvious congestion and edema. However, there were a few inflammatory cells and slight ulcers, and the activities of Na+/K+-ATPase, Ca2+/Mg2+-ATPase and T-ATPase were increased. These findings show that probiotic solution can protect the liver, stomach and intestinal tissue from injury caused by long-time exhaustive exercise, and maintain the integrity and fluidity of cell membrane by increasing Na+/K+-ATPase, Ca2+/Mg2+-ATPase and T-ATPase activities.
