Efficacy and safety of topical versus intravenous tranexamic acid on total knee arthroplasty: a meta-analysis
10.3969/j.issn.2095-4344.0182
- VernacularTitle:氨甲环酸局部应用和静脉注射对全膝关节置换有效和安全性的Meta分析
- Author:
Zhi-Gang SHI
1
;
Bing HAN
;
Yu FU
;
Yin-Sheng WANG
;
Jun LI
;
Jue-Hua JING
Author Information
1. 安徽医科大学第二附属医院骨科
- Keywords:
Arthroplasty;
Replacement;
Knee;
Tranexamic Acid;
Meta-Analysis;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2018;22(11):1798-1804
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Total knee arthroplasty is usually administered by intravenous and topical ways. The two ways have been the focus of research in reducing perioperative blood loss and blood transfusion rate. OBJECTIVE:To evaluate the effects of topical tranexamic acid versus intravenous tranexamic acid on blood loss and blood transfusion rate after total knee arthroplasty and analyze whether they increased the occurrence of postoperative thromboembolic events. METHODS: Electronic databases: PubMed, Embase, Cochrane library, Wanfang and CNKI from inception to 1 August 2016 were searched for studies on the use of tranexamic acid after total knee arthroplasty. The studies meeting the criteria were included. The quality of the included studies was evaluated. Extracted data were analyzed using Revman 5.3 software for meta-analysis. RESULTS AND CONCLUSION: (1) Twelve randomized controlled trials involving 1 159 patients (548 cases of topical application; 611 cases of intravenous injection)were included.(2)There were no significant differences in perioperative total blood loss(WMD=-4.22,95%CI:-10.87–2.43,P>0.05),postoperative drainage(MD=25.03,95% CI:-30.58-80.63,P>0.05),postoperative hemoglobin decline(MD=0.54,95%CI:0.11–0.98,P>0.05),blood transfusion rate(RR=1.15,95CI:0.82-1.61,P>0.05)and incidence of deep venous thrombosis(RR=1.22,95% CI:0.512.89,P>0.05).(3)The best timing for intravenous injection and optimal dose for topical application remain to be further verified.
