Current advances in the drug-loading preparation of poly(lactic-co-glycolic acid) microspheres
10.3969/j.issn.2095-4344.0722
- VernacularTitle:聚乳酸-羟基乙酸共聚物载药微球制备工艺研究进展
- Author:
Xiao-Ming QIU
1
;
Ping ZHEN
;
Song-Kai LI
Author Information
1. 兰州总医院骨科中心
- From:
Chinese Journal of Tissue Engineering Research
2018;22(10):1599-1604
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Existing flaws have been found in the production process of poly(lactic-co-glycolic acid) (PLGA) copolymer microspheres, which lead to residual solvent, low drug loading rate and low encapsulation efficiency of sustained-release microspheres.OBJECTIVE: To review different methods for preparing PLGA microspheres from the following aspects: basic principles, advantages/disadvantages, indications and future development. METHODS: We retrieved CNKI, PubMed and Google scholar to access the articles related to the technique process of preparing PLGA microspheres published from January 2012 to April 2017, including experiment and application research on the principles and advantages/disadvantages of the various processes. RESULTS AND CONCLUSION: To date, the main methods to prepare PLGA microspheres include single/re-emulsion solvent evaporation method, spray drying method, hydrogel template method, microfluid, coaxial electrostatic spraying, phase separation method, and supercritical fluid extraction. However, no valid evidences suggest that there is a technique that completely solves all potential problems, such as drug encapsulation and release, residual solvent and appropriate shape and size. Combination and modification of the production processes is expected to develop novel PLGA microspheres with ideal encapsulation efficiency and stable drug release.
