Application prospects of compound gelatin-methacryloyl hydrogel in bone tissue engineering
10.3969/j.issn.2095-4344.0721
- VernacularTitle:复合明胶甲基丙烯基水凝胶在骨组织工程中的应用及前景
- Author:
Zhao-Xing LIU
1
;
Xing WU
;
Huan-Huan LIN
;
Sha LIU
;
Xiang-Jun CHEN
Author Information
1. 内蒙古医科大学研究生学院
- From:
Chinese Journal of Tissue Engineering Research
2018;22(10):1593-1598
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Compound gelatin-methacryloyl (GelMA) hydrogel has been shown to have unique advantages in bone, cartilage, myocardium, and vascular regeneration.OBJECTIVE: To summarize the novel progress of compound GelMA hydrogel for bone tissue engineering. METHODS: PubMed database and CNKI database from 2010 to 2017 were searched by using the keywords of "gelatin, methacrylamide, hydrogel, hydroxyapatite, bone tissue engineering, bone regeneration, seed cells, microenvironment" in Chinese and English, respectively. RESULTS AND CONCLUSION: Inorganic components can be added in a specific way into the compound GelMA hydrogel to prepare tissue-engineered bone using photolithography, microfluidics, microfabrication and 3D printing techniques. The prepared tissue-engineered bone has similar structural, mechanical and biological properties to natural bone tissue, and importantly, it has osteogenic ability. Gene-modified seed cells that are co-cultured with the compound GelMA hydrogel in a 3D environment are found to grow well and express some genes related to bone regeneration and vascular regeneration. Therefore, the compound GelMA hydrogel has a good osteogenesis effect in vitro,which is an excellent material for bone tissue engineering.
